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I am a total skeptic. I’ve been a successful psychotherapist for 25 years. I’ve had mood difficulties my entire life and have consumed the usual therapies, medications and hormone replacement therapies and remedies without a “cure”. What was most helpful about this book was the distinction Ross invites you to make between emotions caused by real events and thoughts versus “false moods” that are physiological states. Psychotherapy doesn’t help correct physiological imbalances as efficiently as seeking a physiological remedy. Next, with a simple quiz, she divides these mood states into four basic catagories and invites you to locate yourself into a catagory or two based upon the prevalance of certain symptoms. So far, this is like a detective story with you and your symptoms as the main focus. The plot thickens: She educates you about the nature of the physical imbalance implied by your answers and explains the action of the recommended nutritional supplements aimed at your specific hypothetical problem. She tells you how to know by your response whether it is working and how to recognize when you’ve gone too far and should stop the intervention. Well, I was desperate. I decided to follow her regimen to the letter. Surprise! Her predictions were absolutely true to my own responses. If she says you can feel a supplement start to work in 10 minutes, then that is what it does. If she saya it takes months, then it does. BUT IT WORKED for me. It is 18 months since I first followed her advice and after a year or more of no supplements, some symptoms began to return. I’m not kidding when I tell you that the results are just as dramatic this time. I’m sold on her advice. One important result of reading this book is that I’ve learned to differentiate between when I am having a physical problem and when it is an emotional problem. Once you know this, you are more adept at choosing whether to seek psychotherapy, nutritional therapy, or hormonal therapy to address your psychological symptoms. No kidding, this book has set the ground work for me to have a similar quality of life in my post menopausal years as I had as a healthy young person. It restores hope because it applies logic and science. Another helpful thing she said that seems obvious in retrospect is that the “minimal daily requirements” are just that: Minimal to Prevent Symptoms of Disease. Think about it. These guidelines do not spell out “Optimal Daily Requirements” for good health. One note of caution: If you follow her advise too haphazardly or don’t stick to the regimen, you will have less than a dramatic response and you will quickly relapse. Really do it. Take the so called “megadoses” for a month or two, while observing the safety precautions she spells-out and you will be amazed. I was. My body told me that I was on the right track almost right away so my initial misgivings about taking supplements were quickly allayed by the obvious better energy and health I was achieving. When I began, I had been so exhausted that for many years, even mild exercise left me feeling wiped out. Now, I am very active again, my depression and anxiety is minimal and I am now rebuilding my physical fitness. I did check out the assertions she makes with other articles in her subject areas, and although I am a lay person, her advise does appear to check out with mainstream research. Good luck! I’ve reread this book 5-6 times and am still consulting it.